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Collaborative for REMS Education (CO*RE)

The misuse and abuse of extended-release and long-acting (ER/LA) opioids is a major public health problem. Centers for Disease Control and Prevention reported the following:


  • From 2000 to 2015 more than half a million people died from drug overdoses.
  • 91 Americans die every day from an opioid overdose.


CAFP recognizes the public health imperative to address the opioid crisis and has partnered with other organizations to provide continuing education to health care providers across the country. CAFP is a founding member of CO*RE, a group of 10 health care professional organizations that provides opioid education and information about the latest on state level data, regulations and laws related to opioids.


The CO*RE/CAFP Pain Management and Opioids: Balancing Risks and Benefits course addresses this public health crisis. This comprehensive course was developed by renowned experts from Collaborative for REMS Education (CO*RE) and incorporates all six units outlined in the FDA Blueprint for safe opioid prescribing. The updated course also provides necessary context for safe opioid prescribing by discussing biopsychosocial aspects of pain, the newest clinical guidelines on the treatment of chronic pain and state policies about prescribing opioids.


Across the country, more than 10,500 learners have participated in the opioid continuing education activities provided by CAFP (more than 750,000 learners have received education from all CO*RE partners). If you are interested in hosting a course for your organization, contact Jerri Davis at



Who Should Attend

The intended audience is all prescribers of ER/LA opioids including: pain specialists, primary care physicians, physician assistants, nurse practitioners, advanced practice nurses, dentists, addiction medicine physicians, psychiatrists and other physicians and clinicians.


Learning Objectives

  • Accurately assess patients with pain for consideration of an opioid trial.
  • Establish realistic goals for pain management and restoration of function.
  • Initiate opioid treatment (IR and ER/LA) safely and judiciously, maximizing efficacy while minimizing risks.
  • Monitor and re-evaluate treatment continuously; discontinue safely when appropriate.
  • Counsel patients and caregivers about use, misuse, abuse, diversion, and overdose.
  • Educate patients about safe storage and disposal of opioids.
  • Demonstrate working knowledge and ability to access general and specific information about opioids, especially those used in your practice.

*This course is not intended to advocate for the use of ER/LA opioids, but to ensure proper education about safe prescribing practices should a medical provider determine that ER/LA opioids are the best course of treatment.


RPC Commercial Support Disclosure Statement:
This educational activity is supported by an independent educational grant from the ER/LA Opioid Analgesic REMS Program Companies (RPC). Please see for a listing of the member companies.


This activity is intended to be fully-complaint with the ER/LA Opioid Analgesic REMS education requirements issued by the US Food & Drug Administration (FDA).


Additional Resources

Review guidance from the AMA on the safe storage and disposal of medications.
Use the DEA locator to find a controlled substance disposal location near you!
California Department of Public Health, Safe and Active Communities (SAC) Branch Statewide Opioid Safety (SOS) Workgroup
American Family Physician - "Opioid Epidemic - Key Resources" page